NFL Week 5: International Game, Star Returns, and Season-Defining Matchups

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October 7, 2025

Week 5 of the 2025 NFL season delivers an exciting slate that includes the season's first international game, the return of injured quarterbacks, and several matchups with potential to alter the season's trajectory. While some teams enter their first bye week, others will seek escape from crisis or confirmation of strong starts. Here's what awaits in the weekend's action.

International Showcase: NFL Returns to London

Minnesota Vikings vs. Cleveland Browns (Sunday, 9:30 AM ET)

The NFL's London debut for 2025 features rookie Dillon Gabriel making his starting quarterback debut for the Browns. This early-morning kickoff for American viewers brings international flair to Week 5, with the Vikings looking to maintain momentum while Cleveland tests whether their first-round draft pick is ready for prime time.

Gabriel enters a challenging situation - starting on foreign soil against a Vikings defense that has been stout early in the season. His ability to handle the moment will provide crucial insight into Cleveland's future.

Former Teammates Face Off

Tampa Bay Buccaneers vs. Seattle Seahawks

This matchup features a compelling quarterback storyline as former Carolina Panthers teammates Baker Mayfield and Sam Darnold face each other. Both signal-callers have found new homes and varying degrees of success, making their reunion particularly intriguing.

Mayfield has established himself as Tampa Bay's franchise quarterback, while Darnold continues his career resurrection in Seattle. Their contrasting paths since leaving Carolina provide a fascinating subplot.

Key Quarterback Returns

Los Angeles Chargers vs. Washington Commanders

Jayden Daniels returns from injury for Washington, facing a Chargers team eager to capitalize on momentum. The rookie's health and effectiveness will be critical for the Commanders' playoff aspirations.

Baltimore Ravens vs. Houston Texans

The Ravens face a significant challenge without Lamar Jackson, who remains sidelined with a hamstring injury. Baltimore's depth at quarterback will be tested against a Texans team that has shown flashes of competitiveness. This game could prove pivotal in the AFC North race if the Ravens struggle without their two-time MVP.

Prime-Time Showdowns

Buffalo Bills vs. New England Patriots (Sunday Night Football)

The AFC East rivalry takes center stage under the lights. Buffalo enters as clear favorites, but divisional games rarely follow conventional logic. The Patriots' ability to compete with their bitter rivals will reveal whether they're rebuilding or merely retooling.

Jacksonville Jaguars vs. Kansas City Chiefs (Monday Night Football)

Jacksonville hosts Monday Night Football for the first time in two years, facing the daunting task of containing Patrick Mahomes and the Chiefs. The potential debut of rookie sensation Travis Hunter (WR/CB) adds intrigue to this matchup.

Hunter's two-way prowess could provide a unique challenge for Kansas City's offense while offering the Jaguars an additional weapon. If he plays both ways, it would be one of the season's most compelling storylines.

Other Notable Matchups

Denver Broncos vs. Philadelphia Eagles

Two teams with playoff aspirations meet in what could be a statement game. The Eagles' offense against Denver's improving defense promises compelling football.

Carolina Panthers vs. Miami Dolphins

The unpredictable Panthers (1-3) have shown dramatic performance swings early in the season. Miami needs to avoid a letdown against a team capable of surprising stronger opponents.

New York Giants vs. New Orleans Saints

Jaxson Dart makes his first road start for the Giants, facing a Saints team searching for defensive consistency. How Dart handles a hostile environment will be crucial for New York's evaluation of their rookie quarterback.

Expert Analysis and Predictions

Eric Cohen of SportsLine brings exceptional credibility with a 70% success rate in straight-up picks (44-19-1). His Week 5 predictions include:

  • Chargers over Commanders 29-23: Cohen recommends the Chargers money line, over on total points, and an Omarion Hampton touchdown
  • His track record suggests these predictions carry significant weight for betting considerations

Bleacher Report analysts are targeting home underdogs this week, suggesting the betting markets may be undervaluing teams playing at home despite recent struggles.

First Bye Weeks of the Season

Four teams enter their bye weeks in Week 5:

  • Atlanta Falcons
  • Chicago Bears
  • Green Bay Packers
  • Pittsburgh Steelers

These teams will use the break to heal injuries, evaluate early-season performance, and prepare for the second quarter of the season. For some, the timing couldn't be better; for others, the break interrupts positive momentum.

Betting Perspective

Week 5 presents several intriguing betting opportunities:

Value Plays:

  • Home underdogs appear undervalued based on expert analysis
  • The over in Chargers-Commanders fits the profile of both teams' offensive capabilities
  • Browns moneyline offers value if Gabriel exceeds modest expectations

Risk Areas:

  • Ravens without Jackson face significant uncertainty
  • Prime-time games often produce unexpected results
  • International games can be unpredictable due to travel and unfamiliar conditions

Props to Consider:

  • Omarion Hampton touchdown (expert recommendation)
  • Travis Hunter anytime touchdown if he plays offense
  • First touchdown scorer markets in high-scoring affairs

Conclusion

Week 5 represents the NFL season's transition point. Teams entering bye weeks can reflect on quarter-season performance, while those playing face potentially season-defining matchups. From London's early kickoff through Monday night in Jacksonville, this week promises drama, surprises, and clarity about which teams are legitimate contenders.

The international game showcases the NFL's global reach, quarterback returns test team depth and resilience, and prime-time games offer stages for statement performances. Whether you're watching for pure entertainment or have betting interests, Week 5 delivers compelling storylines from kickoff through the final whistle.

Thanks to Stats Perform for the data

Photo:Sports Betting Dime

More information:24live.com

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